Studies indicate that DFF sensor can be a valuable tool for wet granulation formulation and process development and scale-up, as well as for routine monitoring and control during manufacturing. Although this study did not intend to identify ideal granulation end point, these PAT tools can be correlated to end point established independently, such as by statistically significant correlations established through design-of-experiment studies of the effect of process parameters on drug product CQAs.

Journal of Pharmaceutical Sciences, 2016