Lenterra will be presenting on the International Granulation Workshop in Hamburg, Germany
June 25, 2025 2025-06-25 20:23Lenterra will be presenting on the International Granulation Workshop in Hamburg, Germany
Lenterra will be presenting on the International Granulation Workshop in Hamburg, Germany
GoWP Lenterra will be presenting on the International Granulation Workshop in Hamburg, Germany
June 2025
We will deliver an oral presentation “Correlation of granule and tablet properties with real-time in-line DFF sensor measurements in HSWG” at the 11th International Granulation Workshop, Hamburg, Germany on July 2nd, 2025 (https://www.sheffield.ac.uk/media/97581/download?attachment). We will present real-time measurements of acetaminophen granulation in Lenterra Mini Mixer.
Granulation fingerprints measured by our inline rheometer (LIR) were collected for variety of API concentrations and amount of water added. A strong correlation was observed between salient features of the measured signals and particle size distributions for different water contents, allowing for identification of optimal amount of water. The result was confirmed by the tablet dissolution measurements. In addition, a correlation was found between the time when a characteristic feature (a minimum of CVFPM and a maximum of MFPM) appears on the measured evolutions and the tablet dissolution times. The technology also allowed to identify the time interval for the granulation end point. The results of this study indicate that LIR can be used as a tool for formulation development, scale-up, as well as for real-time monitoring and control of high shear wet granulation
About Lenterra
Lenterra Inc., a New Jersey corporation, a developer of innovative micro-optical sensing technologies for mechanical forces in gases and liquids, his recently expanded its portfolio to powder characterization and powder flow measurements. Company’s flagship product – Lenterra Inline Rheometer (LIR) - is a unique instrument that employs patented Drag Force Flow (DFF) sensor and is capable to continuously monitor flow force, powder uniformity and temperature during processing. With years of experience, Lenterra is well skilled in addressing user’s individual flow characterization challenges, focusing on delivering a reliable solution for in-process material characterization, formulation development, scale-up, quality control, or other areas. More at www.lenterra.com.
