A study published recently in the International Journal of Pharmaceutics (https://www.sciencedirect.com/science/article/pii/S0378517324006392) shows, in particular, that Lenterra in-line measurements provide unique and rich information about the granulation process. This study demonstrates that the Lenterra Inline Rheometer (LIR) is capable of signaling the time instant at which the binding liquid is evenly distributed within the dry powder bed, which further reveals the initiation of particle agglomeration. Furthermore, the integrated force and force pulse magnitude (FPM) during the water addition phase are shown to be valuable measurements in approximating granule properties (such as specific energy and basic flowability energy) and predicting tablet tensile strength. The capability of predicting tablet tensile strength and compaction force from upstream data will minimize waste and eliminate operator trial runs to get the best compression machine settings.

“We are very excited to see that this joint UoB and GSK study demonstrated capabilities of Lenterra’s technology in prediction of table properties during high shear wet granulation. With this study we are even more confident that LIR will soon be widely recognized as a unique PAT tool for monitoring and control in pharmaceutical processing”, noted Vadim Stepaniuk, Director of Operations at Lenterra Inc.