Lenterra has developed a methodology for water content optimization in HSWG using its inline rheometer
July 23, 2025 2025-07-25 16:47Lenterra has developed a methodology for water content optimization in HSWG using its inline rheometer
Lenterra has developed a methodology for water content optimization in HSWG using its inline rheometer
GoWP Lenterra has developed a methodology for water content optimization in HSWG using its inline rheometer
July 2025
The company has completed a study measuring fingerprints for granulations of acetaminophen formulations with different API content and varied water addition amount using Lenterra Inline Rheometer (LIR). The fingerprints were compared with results of PSD analysis of the powder released after granulation and with the tablet dissolution tests. The comparison demonstrated a strong correlation between salient features of the fingerprints measured by LIR and particle size distributions for different water amounts added during granulation. Based on the measured process fingerprints, it was possible to reliably identify the water amount that is optimal for granulation. In addition, a correlation was found between the time when a characteristic feature appears on the LIR measurements and dissolution times of the tablets. The technology also identified the time interval that is suitable for ending granulation and determination of the end point. Overall, the study highlighted excellent capabilities of LIR as a tool for formulation development, scale-up, as well as real-time monitoring and control of HSWG.
The results were reported on at the 11th International Granulation Workshop, Hamburg, Germany on July 2nd, 2025 (https://www.sheffield.ac.uk/media/97581/download?attachment). The paper can be found here.
About Lenterra
Lenterra Inc., a New Jersey corporation, a developer of innovative micro-optical sensing technologies for mechanical forces in gases and liquids, his recently expanded its portfolio to powder characterization and powder flow measurements. Company’s flagship product – Lenterra Inline Rheometer (LIR) - is a unique instrument that employs patented Drag Force Flow (DFF) sensor and is capable to continuously monitor flow force, powder uniformity and temperature during processing. With years of experience, Lenterra is well skilled in addressing user’s individual flow characterization challenges, focusing on delivering a reliable solution for in-process material characterization, formulation development, scale-up, quality control, or other areas. More at www.lenterra.com.
